Good news for psoriasis patients: Denmark develops special patch with long-lasting efficacy

Psoriasis is a common and stubborn skin disease. Patients need to apply medication frequently every day to relieve symptoms, but many people are troubled by the greasy medication and cumbersome treatment. This time, Danish scientists invented a special drug patch that is dry and non-greasy, so that patients only need to change it once a day to get good treatment.

Psoriasis is also known as psoriasis and psoriasis. The main symptom is the appearance of silvery white scales around the red rash. Psoriasis is divided into common psoriasis, guttate psoriasis, erythrodermic psoriasis, pustular psoriasis and inverse psoriasis. These rashes vary in form, size and severity and are prone to occur on the scalp, elbows, knees or behind the ears.

The medical community generally believes that this disease is caused by an overactive immune system, which leads to excessive proliferation of skin cells. It may also be related to genetic and environmental factors. There is currently no complete cure for psoriasis, but a variety of treatments can play a control role. Common treatment agents for mild patients are creams, ointments or gels, but these ointments must be applied several times a day to effectively suppress the disease. Many psoriasis patients cannot adhere to the treatment because the treatment is too troublesome or the skin is greasy. In addition, moderate or severe patients often need to be treated with stronger drugs, injections, etc.

In order to solve the problem of patients’ inability to adhere to treatment, the 540-year-old School of Health and Medical Sciences at the University of Copenhagen in Denmark uses electrospinning, which has anti-inflammatory properties, to make a special drug patch that allows psoriasis patients to receive easier and more effective treatment. This treatment method can also be used to treat other types of skin diseases.

Electrospinning was chosen as a dressing because it can not only be used for wound dressing and drug delivery, but also has the properties of helping wound repair and anti-inflammatory. In addition, this fiber dressing itself is elastic and flexible, easy to remove, and its mechanical properties remain unchanged even after adding drugs.

The researchers used a hydrophobic polymer polycaprolactone (PCL) as the fabric for electrospinning, allowing this thing to be attached to the skin like a patch. This patch is mainly divided into three layers, the outermost electrospinning contains active agents, the middle layer of electrospinning contains cortisol (hydrocortisone), and the innermost layer of electrospinning contains salicylic acid.